Program: PhD Track: Medicinal Chemistry Advisor: Xiang-Qun (Sean) Xie, PhD, EMBA
To become a radiotherapy doctor, I graduated from School of Medicine in Soochow University with MD degree. My professional career started from Radiotherapy Center in Changhai Hospital in China. By working as a resident doctor in Changhai hospital for 1 year, I learnt diagnosing tumor and making therapy plan for individual tumor patient. 3DCRT (3-dimensional conformal radiation therapy) and IMRT (Intensity-modulated radiation therapy) are major techniques we used. Besides tumor treatment, we also performed total body irradiation on leukemia patients before transplantation. Another my expertise is performing radiotherapy on Graves’ Disease, which requires accurate localization of radiotherapy targeting. With certain experience on operating irradiator, especially for leukemia patients who needed transplantation, Dr. Tao Cheng, who was professor in Department of Radiation Oncology in University of Pittsburgh, invited me as Visiting Scholar in his laboratory. I was involved in a project named “negative effects of irradiated hosts on transplanted Hematopoietic Stem Cells (HSCs)” aiming to quantify the negative effects, the mechanisms, and improvement of HSC engraftment by manipulating irradiated host microenvironment. During the following 3 years’ laboratory work, I took in charge of mice breeding, Hematopoietic Stem Cell transplantation on mice, operating irradiator to irradiate mice. In 2012, as a co-author, we published a paper in Blood based on our finding related to the negative effect of residual radiation on transplanted host, the correlation between Reactive Oxygen Species (ROS) and stem cell growth factor receptors (c-kit) down-regulation. To obtain formal PhD training in Pharmaceutical Sciences, I have been admitted to University of Pittsburgh School of Pharmacy as PhD student since 2013. In the first two years, besides course work for PhD training, I devoted most of my time for research to a project “small molecules virtual screening for Hematopoietic Stem Cell ex vivo expansion” by setting up knowledgebase of signaling pathways related to stem cell self-renew and performing radioactive isotope marked bioassay for small molecules binding validation. After finishing course work, I joined in Dr. Johnny Huard’s lab in UTHealth to achieve my major project for my PhD dissertation on muscle-derived stem/progenitor cell.
Stem Cell Biology, Hematopoietic Stem Cell Transplantation, Muscle-derived Stem Cell aging
1. Shen, Hongmei, Hui Yu, Paulina H. Liang, Haizi Cheng, Richard XuFeng, Youzhong Yuan, Peng Zhang, Clayton A. Smith, and Tao Cheng. "An Acute Negative Bystander Effect of Γ-Irradiated Recipients on Transplanted Hematopoietic Stem Cells." Blood 119, no. 15 (2012): 3629-37. http://dx.doi.org/10.1182/blood-2011-08-373621.
2. Li, Yanxin, Haizhong Feng, Haihui Gu, Dale W. Lewis, Youzhong Yuan, Lei Zhang, Hui Yu, Peng Zhang, Haizi Cheng, Weimin Miao, Weiping Yuan, Shi-Yuan Cheng, Susanne M. Gollin, and Tao Cheng. "The P53–Puma Axis Suppresses Ipsc Generation." Nature Communications 4 (2013): 2174. http://dx.doi.org/10.1038/ncomms3174.
3. Miao, Weimin, Richard XuFeng, Moo-Rim Park, Haihui Gu, Linping Hu, Jin Kang, Shihui Ma, Paulina H. Liang, Yanxin Li, Haizi Cheng, Hui Yu, Michael Epperly, Joel Greenberger, and Tao Cheng. "Hematopoietic Stem Cell Regeneration Enhanced by Ectopic Expression of Ros-Detoxifying Enzymes in Transplant Mice." Molecular Therapy 21, no. 2 (2013): 423-32. http://dx.doi.org/10.1038/mt.2012.232.
4. Gao, Yingdai, Peng Yang, Hongmei Shen, Hui Yu, Xianmin Song, Liyan Zhang, Peng Zhang, Haizi Cheng, Zhaojun Xie, Sha Hao, Fang Dong, Shihui Ma, Qing Ji, Patrick Bartlow, Yahui Ding, Lirong Wang, Haibin Liu, Yanxin Li, Hui Cheng, Weimin Miao, Weiping Yuan, Youzhong Yuan, Tao Cheng, and Xiang-Qun Xie. "Small-Molecule Inhibitors Targeting Ink4 Protein P18ink4c Enhance Ex Vivo Expansion of Haematopoietic Stem Cells." Nature Communications 6 (2015): 6328. http://dx.doi.org/10.1038/ncomms7328.
5. Feng, Rentian, Qin Tong, Zhaojun Xie, Haizi Cheng, Lirong Wang, Suzanne Lentzsch, G. David Roodman, and Xiang‐Qun Xie. "Targeting Cannabinoid Receptor‐2 Pathway by Phenylacetylamide Suppresses the Proliferation of Human Myeloma Cells through Mitotic Dysregulation and Cytoskeleton Disruption." Molecular Carcinogenesis 54, no. 12 (2015): 1796-806. http://dx.doi.org/10.1002/mc.22251.
6. Xie, Xiang-Qun, Peng Yang, Yu Zhang, Peng Zhang, Liping Wang, Yahui Ding, Ming Yang, Qin Tong, Haizi Cheng, Qing Ji, Terence McGuire, Weiping Yuan, Tao Cheng, and Yingdai Gao. "Discovery of Novel Ink4c Small-Molecule Inhibitors to Promote Human and Murine Hematopoietic Stem Cell Ex Vivo Expansion." Scientific Reports 5 (2015): 18115. http://dx.doi.org/10.1038/srep18115.
7. Zhang, Y., L. Wang, Z. Feng, H. Cheng, T. F. McGuire, Y. Ding, T. Cheng, Y. Gao, and X. Q. Xie. "Stemcellckb: An Integrated Stem Cell-Specific Chemogenomics Knowledgebase for Target Identification and Systems-Pharmacology Research." J Chem Inf Model 56, no. 10 (Oct 24 2016): 1995-2004. http://dx.doi.org/10.1021/acs.jcim.5b00748.
Haizi Cheng, Xueqin Gao, Aiping Lu, Johnny Huard. Expression levels of cyclin-dependent kinase inhibitors differ between young and old muscle-derived stem cells: implications for cell cycle regulation during aging, ORS 2017, Poster presentation. Southwest ORS symposium 2017, Poster Presentation award.
1. Haizi Cheng, Xueqin Gao, Aiping Lu, Johnny Huard. Expression levels of cyclin-dependent kinase inhibitors differ between young and old muscle-derived stem cells: implications for cell cycle regulation during aging, ORS 2017, Poster presentation. Southwest ORS symposium 2017, Poster Presentation award.
2. Haizi Cheng, Xueqin Gao, Aiping Lu, Johnny Huard. Muscle Derived Stem Cells Naturally Aging Driven by Cell Cycle Regulation. ASGCT 2017, Poster presentation.
3. Haizi Cheng, Xueqin Gao, Aiping Lu, Johnny Huard BMP4 Regulates Cell Cycle Kinetics in Aging Muscle-Derived Stem Cell-mediated Osteogenesis and Bone Regeneration , ORS 2018, Poster presentation.
4. Haizi Cheng, Xueqin Gao, Aiping Lu, Johnny Huard. p18 is required and regulated by BMP4 in Muscle-Derived Stem Cell-mediated Osteogenesis and Bone Regeneration during aging. ASBMR 2018. Oral presentation.