Directory Profile

Keito Hoshitsuki, PharmD

Office: 322 Salk Pavilion

Email: keh112@pitt.edu

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Program: PhD
Track: Clinical Pharmaceutical Sciences
Advisor: Christian Fernandez, PhD

Keito Hoshitsuki is a first year graduate student in the Clinical Pharmaceutical Scientist track at PittPharmacy in the laboratory of faculty member Christian A. Fernandez, PhD. He is a Rho Chi-AFPE fellow and TL1 postdoctoral fellow. Hoshitsuki received his Doctor of Pharmacy degree summa cum laude from the University of Pittsburgh School of Pharmacy with Areas of Concentration in Research and Pediatrics (2017) and completed PGY1 pharmacy practice residency at Children’s Minnesota (2018) and PGY2 specialty residency in Clinical Pharmacogenomics at St. Jude Children’s Research Hospital (2019). His clinical/translational research and practice areas of interest include pharmacogenomics and mechanisms of immune-mediated adverse drug reactions, particularly in the pediatric and hematology/oncology patient populations. He also contributes to clinical pharmacogenomics research and implementation through the Pharmacogenomics Center of Excellence.

Immune-mediated adverse drug reactions and pharmacogenomics

Hoshitsuki K, Molinelli AR, Inaba H, Rubnitz JE, Barker, PJ. Case of metabolic acidosis in a pediatric patient with leukemia and fungal infection. Clin Chem. 2020;66(4):518-22. PMID:32232459

Suiter CC, Moriyama T, Matreyek KA, Yang W, Scaletti ER, Nishii R, Yang W, Hoshitsuki K, Singh M, Trehan A, Parish C, Smith CA, Bhojwani D, Yuen L, Chi-kong Li C, Li C, Yang Y, Walker GJ, Goodhand JR, Kennedy NA, Klussmann FA, Bhatia S, Relling MV, Kato M, Hori H, Bhatia P, Ahmad T, Yoeh AE, Stenmark P, Fowler DM, Yang JJ. Massive parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity. Proc Natl Acad Sci U S A. 2020;117(10):5394–5401. PMID:32094176

Hoshitsuki K, Crews KR, Yang W, Smith CA, Hankins JS, Turner AJ, Broeckel U, McMillin GA, Relling MV, Haidar CE. Challenges in clinical implementation of CYP2D6 genotyping: choice of variants to test affects phenotype determination. Genet Med. 2020;22(1):232–233. PMID:31341243

Jha RM, Molyneaux BJ, Jackson T, Wallisch J, Poloyac S, Vagni V, Janesko-Feldman KL, Hoshitsuki K, Minnigh MB, Kochanek PM. Glibenclamide produces region-dependent effects on cerebral edema in a combined injury model of traumatic brain injury and hemorrhagic shock in mice. J. Neurotrauma. 2018;35(17):2125-35. PMID:29648981

Fuhrman D, Crowley K, Vetterly C, Hoshitsuki K, Koval A, Carcillo J. Medication use as a contributor to fluid overload in the PICU: A Prospective Observational Study. J Pediatr Intensive Care. 2018;7(2):69-74. PMID:31073473

Moriyama T, Nishii R, Perez-Andreu 1, Yang W, Klussmann FA, Zhao X, Lin TN, Hoshitsuki K, Nersting J, Kihira K, Hofmann U, Komada Y, Kato M, McCorkle R, Li L, Koh K, Najera CR, Kham SK, Isobe T, Chen Z, Chiew EK, Bhojwani D, Jeffries C, Lu Y, Schwab M, Inaba H, Pui CH, Relling MV, Manabe A, Hori H, Schmiegelow K, Yeoh AE, Evans WE, Yang JJ. NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. Nat Genet. 2016;48(4):367-73. PMID:26878724

Graduate Program, University of Pittsburgh School of Pharmacy
2020 TL1 Clinical and Translational Science Postdoctoral Fellowship
2019 Rho Chi - AFPE First Year Graduate Fellowship

Doctor of Pharmacy Program, University of Pittsburgh School of Pharmacy
2017 Lilly Achievement Award
2016 University of Pittsburgh School of Pharmacy Bessie Black Kobrin Endowed Fund Scholarship
2015 University of Pittsburgh School of Pharmacy Louis Weinberger Endowed Fund Scholarship
2015 The Rho Chi Society Alpha Omicron Chapter Inductee
2014, 2015 University of Pittsburgh University Scholar
2014 University of Pittsburgh School of Pharmacy F. Gary Haberle Scholarship
2013 University of Pittsburgh School of Pharmacy Reif-Kelly Student Resource Fund Award
2011 – 2015 University of Pittsburgh Full Tuition Honors Scholarship

Others:
2011 – 2015 National Merit Scholarship Corporation – Corporate Sponsored Scholarship
2011 – 2013 Stanley Black & Decker Scholarship

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