Directory Profile
Keito Hoshitsuki, PharmDGraduate Student
Program: PhD Track: Clinical Pharmaceutical Sciences Advisor: Christian Fernandez, PhD
Keito Hoshitsuki, PharmD is a PhD graduate student in the Clinical Pharmaceutical Sciences track at PittPharmacy in the laboratory of faculty member Christian A. Fernandez, PhD. He is a Rho Chi-AFPE fellow and TL1 Postdoctoral fellow. Hoshitsuki received his Doctor of Pharmacy degree summa cum laude from the University of Pittsburgh School of Pharmacy with Areas of Concentration in Research and Pediatrics (2017) and completed PGY1 pharmacy residency at Children’s Minnesota (2018) and PGY2 specialty residency in Clinical Pharmacogenomics at St. Jude Children’s Research Hospital (2019). His clinical and translational research and practice areas of interest include pharmacogenomics and mechanisms of immune-mediated adverse drug reactions, particularly in the pediatric and hematology/oncology patient populations. He also contributes to clinical pharmacogenomics research and implementation through the Pharmacogenomics Center of Excellence (PI: Empey). He serves on several national committees and working groups including in the Pharmacogenomics Global Research Network (PGRN) and Clinical Pharmacogenetics Implementation Consortium (CPIC).
Immune-mediated adverse drug reactions and pharmacogenomics
Hoshitsuki K, Fernandez CA, Yang JJ. Pharmacogenomics for Drug Dosing in Children: Current Use, Knowledge, and Gaps. J Clin Pharmacol. 2021 Jun;61 Suppl 1:S188-S192. doi: 10.1002/jcph.1891. PubMed PMID: 34185912; PubMed Central PMCID: PMC8259917.
McDermott JH*, Wolf J*, Hoshitsuki K, Huddart R, Caudle KE, Whirl-Carrillo M, Steyger PS, Smith RJH, Cody N, Rodriguez-Antona C, Klein TE, Newman WG. Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT-RNR1 Genotype. Clin Pharmacol Ther. 2021 May 25;. doi: 10.1002/cpt.2309. [Epub ahead of print] Review. PubMed PMID: 34032273.
Nishii R*, Baskin-Doerfler R*, Yang W, Oak N, Zhao X, Yang W, Hoshitsuki K, Bloom M, Verbist K, Burns M, Li Z, Lin TN, Qian M, Moriyama T, Gastier-Foster JM, Rabin KR, Raetz E, Mullighan C, Pui CH, Yeoh AE, Zhang J, Metzger ML, Klco JM, Hunger SP, Newman S, Wu G, Loh ML, Nichols KE, Yang JJ. Molecular basis of ETV6-mediated predisposition to childhood acute lymphoblastic leukemia. Blood. 2021 Jan 21;137(3):364-373. doi: 10.1182/blood.2020006164. PubMed PMID: 32693409; PubMed Central PMCID: PMC7819760.
Hoshitsuki K*, Rathod S*, Ramsey MJ, Zhu L, Moreland LW, Fernandez CA. Adalimumab Immunogenicity Is Negatively Correlated with Anti-Hinge Antibody Levels in Patients with Rheumatoid Arthritis. J Pharmacol Exp Ther. 2020 Dec;375(3):488-497. doi: 10.1124/jpet.120.000179. Epub 2020 Oct 2. PubMed PMID: 33008870; PubMed Central PMCID: PMC7718728.
Hoshitsuki K, Molinelli AR, Inaba H, Rubnitz JE, Barker PJ. Metabolic Acidosis in a Pediatric Patient with Leukemia and Fungal Infection. Clin Chem. 2020 Apr 1;66(4):518-522. doi: 10.1093/clinchem/hvz035. PubMed PMID: 32232459; PubMed Central PMCID: PMC7108497.
Suiter CC, Moriyama T, Matreyek KA, Yang W, Scaletti ER, Nishii R, Yang W, Hoshitsuki K, Singh M, Trehan A, Parish C, Smith C, Li L, Bhojwani D, Yuen LYP, Li CK, Li CH, Yang YL, Walker GJ, Goodhand JR, Kennedy NA, Klussmann FA, Bhatia S, Relling MV, Kato M, Hori H, Bhatia P, Ahmad T, Yeoh AEJ, Stenmark P, Fowler DM, Yang JJ. Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5394-5401. doi: 10.1073/pnas.1915680117. Epub 2020 Feb 24. PubMed PMID: 32094176; PubMed Central PMCID: PMC7071893.
Hoshitsuki K, Crews KR, Yang W, Smith CA, Hankins JS, Turner AJ, Broeckel U, McMillin GA, Relling MV, Haidar CE. Challenges in clinical implementation of CYP2D6 genotyping: choice of variants to test affects phenotype determination. Genet Med. 2020 Jan;22(1):232-233. doi: 10.1038/s41436-019-0614-y. Epub 2019 Jul 25. PubMed PMID: 31341243; PubMed Central PMCID: PMC7702299.
Jha RM, Molyneaux BJ, Jackson TC, Wallisch JS, Park SY, Poloyac S, Vagni VA, Janesko-Feldman KL, Hoshitsuki K, Minnigh MB, Kochanek PM. Glibenclamide Produces Region-Dependent Effects on Cerebral Edema in a Combined Injury Model of Traumatic Brain Injury and Hemorrhagic Shock in Mice. J Neurotrauma. 2018 Sep 1;35(17):2125-2135. doi: 10.1089/neu.2016.4696. Epub 2018 Jun 6. PubMed PMID: 29648981; PubMed Central PMCID: PMC6098411.
Fuhrman D, Crowley K, Vetterly C, Hoshitsuki K, Koval A, Carcillo J. Medication Use as a Contributor to Fluid Overload in the PICU: A Prospective Observational Study. J Pediatr Intensive Care. 2018 Jun;7(2):69-74. doi: 10.1055/s-0037-1604422. Epub 2017 Jul 26. PubMed PMID: 31073473; PubMed Central PMCID: PMC6260341.
Moriyama T, Nishii R*, Perez-Andreu V*, Yang W, Klussmann FA, Zhao X, Lin TN, Hoshitsuki K, Nersting J, Kihira K, Hofmann U, Komada Y, Kato M, McCorkle R, Li L, Koh K, Najera CR, Kham SK, Isobe T, Chen Z, Chiew EK, Bhojwani D, Jeffries C, Lu Y, Schwab M, Inaba H, Pui CH, Relling MV, Manabe A, Hori H, Schmiegelow K, Yeoh AE, Evans WE, Yang JJ. NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. Nat Genet. 2016 Apr;48(4):367-73. doi: 10.1038/ng.3508. Epub 2016 Feb 15. PubMed PMID: 26878724; PubMed Central PMCID: PMC5029084.
*denotes equal contribution
Grants
Sponsored Early Career Leukemia/Lymphoma Research Grant (Eichinger) Role: Co-I
Hematology/Oncology Pharmacy Association and Acerta Pharma
Period of Support: 08/2021-08/2022
1 TL1 TR001858 (Kraemer) Role: Postdoctoral Fellow
NIH/NCATS
Period of Support: 5/31/2020 – 5/31/2022
The University of Pittsburgh Clinical and Translational Science Institute – Clinical and Translational Science Fellowship Program
Rho Chi – AFPE First Year Graduate Fellowship Role: PI
The Rho Chi Society and American Foundation for Pharmaceutical Education
Period of Support: 08/2019 – 04/2021
Graduate Program, University of Pittsburgh School of Pharmacy
2020 Journal of Clinical Pharmacology and Experimental Therapeutics Highlighted Trainee Author
Doctor of Pharmacy Program, University of Pittsburgh School of Pharmacy
2017 Lilly Achievement Award
2016 University of Pittsburgh School of Pharmacy Bessie Black Kobrin Endowed Fund Scholarship
2015 University of Pittsburgh School of Pharmacy Louis Weinberger Endowed Fund Scholarship
2015 The Rho Chi Society Alpha Omicron Chapter Inductee
2014, 2015 University of Pittsburgh University Scholar
2014 University of Pittsburgh School of Pharmacy F. Gary Haberle Scholarship
2013 University of Pittsburgh School of Pharmacy Reif-Kelly Student Resource Fund Award
2011 – 2015 University of Pittsburgh Full Tuition Honors Scholarship
Others:
2011 – 2015 National Merit Scholarship Corporation – Corporate Sponsored Scholarship
2011 – 2013 Stanley Black & Decker Scholarship