Directory Profile
Clare Hill, BSGraduate Student
Program: PhD Track: Medicinal Chemistry Advisor: Peter Wipf, PhD
Third year graduate student in the Wipf Group with a focus in medicinal chemistry and natural product total synthesis. Projects include design and development of small molecule heterocycles for the treatment of disease states associated with voltage-gated potassium channels (KCNQ) and total synthesis of C20 diterpinoid alkaloids.
Total Synthesis
Medicinal Chemistry
Goeckeler-Fried JL, Aldrin Denny R, Joshi D, Hill C, Larsen MB, Chiang AN, Frizzell RA, Wipf P, Sorscher EJ, Brodsky JL. Improved correction of F508del-CFTR biogenesis with a folding facilitator and an inhibitor of protein ubiquitination. Bioorg Med Chem Lett. 2021 Sep 15;48:128243. doi: 10.1016/j.bmcl.2021.128243. Epub 2021 Jul 8. PMID: 34246753; PMCID: PMC8869796.
Hernandez CC, Tarfa RA, Miguel I Limcaoco J, Liu R, Mondal P, Hill C, Keith Duncan R, Tzounopoulos T, Stephenson CRJ, O'Meara MJ, Wipf P. Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype. Bioorg Med Chem Lett. 2022 Sep 1;71:128841. doi: 10.1016/j.bmcl.2022.128841. Epub 2022 Jun 4. PMID: 35671848.