Office: 709 Salk Hall
Donna M. Huryn is Research Professor in the Department of Pharmaceutical Sciences, and a PI of the University of Pittsburgh Chemical Diversity Center (UP-CDC). She also holds an Adjunct Professor appointment at the University of Pennsylvania’s Department of Chemistry. She received her B.A. from Cornell University, and Ph.D. in synthetic organic chemistry from Penn.
After graduate school, she joined the Chemistry Research Department at Hoffmann-La Roche, Inc, and contributed to drug discovery efforts in inflammation, HIV, and cancer. In 1997 she joined Wyeth Research, in the Chemical Sciences department. She held a number of positions there, including Director of CNS Medicinal Chemistry and Director of the Chemical Sciences Interface Department. Under her leadership, compounds entered clinical trials for asthma, Alzheimer’s disease, schizophrenia and depression. In 2004, she left the pharmaceutical industry to join academia, where her research interests include the identification of small molecule probes of biological systems, particularly those targetting cancer, infectious disease and neurodegenerative disorders.
Professor Huryn has served as a permanent member of several NIH Medical Chemistry A Study Section, and was a member of the NSF Committee of Visitors. She has held a number of elected positions within the American Chemical Society at both the local and national levels, and is an Associate Editor to ACS Medicinal Chemistry Letters, member of the Editorial Advisory board of Organic Letters, and a Fellow of the American Chemical Society
My research interests involve the design, synthesis and optimization of small molecule probes of biological systems, with a particular focus on targets involved in cancer, neurodegenerative diseases and infectious diseases.
“A New Synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-c]pyrimidines by a Retro-Mannich Cascade Rearrangement,” R. Colombo, K.O. Jeon, D.M. Huryn, M.G. LaPorte, P. Wipf, Austr. J. Chem. 2013, 67, 420-425.
“Contributions of Academic Labs to the Discovery and Development of Chemical Biology Tools,” D.M. Huryn, L. Resnick, P. Wipf, J. Med. Chem. 2013, 65, 7161-7176.
“Drug Discovery in an Academic Setting: Playing to the Strengths,” D.M. Huryn, Med. Chem. Lett. 2013, 4, 313-315.
“Carboxylic Acid (Bio)Isosteres in Drug Design,” C. Ballatore, D. M. Huryn, A.B. Smith, III ChemMedChem. 2013, 8, 385-395.
“Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies,” C. Ballatore, K.R. Brunden, D.M. Huryn, J.Q. Trojanowski, V.M.-Y. Lee, A.B. Smith, III, J. Med. Chem. 2012, 55, 8979-8996.
“Bulged DNA Substrates for Identifying Poxvirus Resolvase Inhibitors,” M. Culyba, Y. Hwang, S. Attar, P.B. Marid, J. Bupp, D. Huryn, L. Sanchez, J.Grobler, M.D. Miller, F.D. Bushman, Nucleic Acids Res. 2012 [Epub]
“Identification and Characterization of Small Molecule Antagonists of pRb Inactivation by Viral Oncoproteins,” D. Fera, D.C. Schultz, S. Hodawadekar, M. Reichman, P. S. Donover, J. Melvin, S. Troutman, J. Kissil, D.M. Huryn, R. Marmorstein, Chem, & Bio. 2012, 19, 518-528.
“Cyclopentane-1,2-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2) Receptor Antagonists,” C. Ballatore, J.H. Soper, F. Piscitelli, M. James, L. Huang, O. Atasoylu, D.M. Huryn, J.Q. Trojanowski, V.M. Lee, K.R. Brunden, A.B, Smith, J. Med. Chem. 2011, 54, 6969-6983.
“Chemical Methodology as a Source of Small Molecule Checkpoint Inhibitors and Heat Shock Protein 70 (Hsp70) Modulators,” D.M. Huryn, J.L. Brodsky, K.M. Brummond, P.G. Chambers, B. Eyer, A.W. Ireland, M. Kawasumi, M.G. LaPorte, K. Lloyd, B. Manteau, P. Nghiem, B. Quade, S.P. Seguin, P.Wipf, Proc. Natl. Acad. Sci USA 2011, 108, 6757-6762.
“Modulation of Protein-Protein Interactions as a Therapeutic Strategy for the Treatment of Neurodegenerative Tauopathies,” C. Ballatore, K.R. Brunden, J.Q. Trojanowski, V.M-Y. Lee, A.B. Smith, III, D.M. Huryn, Curr. Topics Med. Chem. 2011, 11, 317-330.
“Identification of Novel Inhibitors of Dietary Lipid Absorption Using Zebrafish,” J.D. Clifton, E. Lucumi, M.C. Myers, A. Napper, K. Hama, S.A. Farber, A.B. Smith, III, D.M. Huryn, S.L. Diamond, M. Pack, PLoSOne 2010, 5, e12386.
“A Small Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks SARS and Ebola Pseudotype Virus Infection into HEK 293T Cells,” P.P. Shah, T. Wang, R.L. Kaletsky, M. Myers, J.E. Puvis, H. Jing, D.M. Huryn, D.C. Greenbaum, A.B. Smith, P. Bates, S.L. Diamond, Mol. Pharm. 2010, 78, 319-324.
“Design, Synthesis and Biological Evaluation of a Library of Thiocarbazates and Their Activity as Cysteine Protease Inhibitors,” Z. Liu, M.C. Myers, P.P. Shah, M.P. Beavers, P.A. Benedetti, S.L. Diamond, A.B. Smith, D.M. Huryn, Combin. Chem. High Throughput Screen. 2010, 4, 337-351.
“Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein Gamma-secretase for the Treatment of Alzheimer’s Disease,” R.L. Martone, H. Zhou, K. Atchison, T. Comery, J.Z. Xu, X. Huang, X. Gong, M. Jin, A. Kreft, B. Harrison, S.C. Mayer, S. Aschmies, C. Gonzales, M.M. Zaeska, D.R, Riddell, E. Wagner, P. Lu, S.C. Sun, J. Sonnenberg-Reines, A. Oganesian, K. Adkins, M.W. Leach, D.W. Clarke, D. Huryn, M. Abou-Gharbia, R. Magolda, J. Bard, G. Frick S. Raje, S.B. Forlow, C. Balliet, M.E. Burczynski, R.H. Reinhart, H.I, Wan, M.N. Pangalos, J.S. Jacobsen, J. Parmacol. Exp. Ther. 2009, 331, 598-608.
“Identification of Aminothienopyridazine Inhibitors of Tau Assembly by Quantitative High-throughput Screening,” A. Crowe, W. Huang, C. Ballatore, R. Johnson, A.-M. L. Hogan, R. Huang, J. Wichterman, J. McCoy, D. Huryn, D.S. Auld, A.B. Smith, J. Inglese, J.Q. Trojanowski, C. Austin, K.R. Brunden, V. M.-Y. Lee, Biochem. 2009, 48, 7732-7745.
“Synthesis and Structure-Activity Relationship of a Novel Series of Heterocyclic Sulfonamide γ-Secretase Inhibitors,” J. Pu, A.F. Kreft, S.H. Aschmies, K.P. Atchison, J. Berkowitz, T.J. Caggiano, M. Chlenov, G. Diamantidis, B.L. Harrison, Y. Hu, D. Huryn, J.S. Jacobsen, M. Jin, K. Lipinski, P. Lu, R.L. Martone, K. Morris, J. Sonnenberg-Reines, D.R. Riddell, J. Sabalski, S-C. Sun, E. Wagner, Y. Wang, Z. Xu, H. Zhou, L. Resnick, Bioorg. Med. Chem. 2009, 17, 4708-4717.
“Select Pyrimidinones Inhibit the Propagation of the Malarial Parasite, Plasmodium Falciparum,” A.N. Chiang, J.-C. Valderramos, J.C. Balachandran, R.J. Chovatiya, B.P. Mead, C. Schneider, S.L. Bell, M.G. Klein, D.M. Huryn, X.S. Chen, B.W. Day, D.A Fiddock, P. Wipf, J.L. Brodsky, Bioorg. Med. Chem. 2009, 17, 1527-1533.
“Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease,” S.C. Mayer, A.F. Kreft, B. Harrison, M. Abou-Gharbia, M. Antane, S. Aschmies, K. Atchison, M. Chlenov, D.C. Cole, T. Comery, G. Diamantidis, J. Ellingboe, K. Fan, R. Galante, C. Gonzales, D.M. Ho, M.E. Hoke, Y. Hu, D. Huryn, U. Jain, M. Jin, K. Kremer, D. Kubrak, M. Lin, P. Lu, R. Magolda, R. Martone, W. Moore, A. Oganesian, M.N. Pangalos, A. Porte, P. Reinhart, L. Resnick, D.R. Riddell, J. Sonnenberg-Reines, J.R. Stock, S.-C. Sun, E.. Wagner, T. Wang, K. Woller, Z. Xu, M.M. Zaleska, J. Zeldis, M. Zhang, H. Zhou and J.S. Jacobsen, J. Med. Chem. 2008, 51, 7348–7351.
“Design, Synthesis and Evaluation of Inhibitors of Cathepsin L: Exploiting a Unique Thiocarbazate Chemotype,” M.C. Myers, P.P. Shah, M.P. Beavers, A.D. Napper, S.L. Diamond, A.B. Smith, D.M. Huryn, Bioorg. Med. Chem. Lett. 2008, 18, 3636-3651.
“The Future of Alzheimer’s Disease: New Therapies for an “Old” Disease,” Association for Women in Science – Philadelphia Chapter, Philadelphia, PA; March 2011.
“Adventures in Academic Drug Discovery: Identification, Characterization and Optimization of Novel Inhibitors of Cathepsin L - a Potential Drug Target to Treat SARS and Ebola,” Medicinal Chemistry and Drug Discovery Mini-Symposium, Indian Institute of Chemical Technology, Hyderabad, India; April 2011.
“The Future of Alzheimer’s Disease Therapy: New Treatment for an ‘Old’ Disease,” INDO-US Symposium on Frontiers in Medicinal Chemistry and Drug Discovery, JSS University, Mysore, India; April 2011.
“Adventures in Academic Drug Discovery,” ACS Mid-Atlantic Regional Meeting (MARM) 2012, University of Maryland, Baltimore County (UMBC), May/June 2012.
“Are We Closer to Building a Perfect Screening Library, Society for Laboratory Automation & Screening (SLAS), Orlando, FL, January 2013.