Dr. Philip Empey is the Associate Director for Pharmacogenomics of the Pitt/UPMC Institute of Precision Medicine and leads the PreCISE-Rx and Test2Learn teams to implement pharmacogenomics clinical, research, and educational initiatives. As a clinician-scientist in the Department of Pharmacy and Therapeutics, Dr. Empey conducts NIH-funded clinical and translational research aimed at understanding the mechanisms of the variability in drug response to improve medication-related outcomes in critically-ill patients.
He received his PharmD from the University of Rhode Island and completed PGY1 and PGY2 residencies in Pharmacy Practice and Critical Care at the University of Kentucky. He earned a PhD in Clinical Pharmaceutical Sciences at the University of Kentucky before completing postdoctoral research training at the University of Pittsburgh.
Current research interests include understanding the role/impact of xenobiotic transporters following neurological injury, transporter pharmacogenomics, pharmacogenomics clinical implementation, collection of medication-related phenotype information, and genotype-phenotype discovery. Dr. Empey teaches at the graduate level in pharmacokinetics, pharmacogenomics, and drug transporters in the Schools of Pharmacy, Medicine, and Nursing. He also has a research interest in innovative educational models to transform education.
Role of transporters in drug disposition and pathophysiology in critical care patients; clinical importance of pharmacogenomics in drug response.
Du L, Empey PE, Ji J, Chao H, Kochanek PM, Bayır H, Clark RS. Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro. J Neurotrauma. 2016 Mar 22. PMID: 26830358.
Kochanek PM, Bramlett HM, Shear DA, Dixon CE, Mondello S, Dietrich WD, Hayes RL, Wang KK, Poloyac SM, Empey PE, Povlishock JT, Mountney A, Browning M, Deng-Bryant Y, Yan HQ, Jackson TC, Catania M, Glushakova O, Richieri SP, Tortella FC. Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy. J Neurotrauma. 2016 Mar 15;33(6):606-14. doi: 10.1089/neu.2015.4133. PMID: 26671284.
Dixon CE, Bramlett HM, Dietrich WD, Shear DA, Yan HQ, Deng-Bryant Y, Mondello S, Wang KK, Hayes RL, Empey PE, Povlishock JT, Tortella FC, Kochanek PM. Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. J Neurotrauma. 2016 Mar 15;33(6):553-66. doi: 10.1089/neu.2015.4122. PMID: 26671075.
Mountney A, Bramlett HM, Dixon CE, Mondello S, Dietrich WD, Wang KK, Caudle K, Empey PE, Poloyac SM, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM, Shear DA. Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. J Neurotrauma. 2016 Mar 15;33(6):567-80. doi: 10.1089/neu.2015.4130. PMID: 26541177.
Adams SM, Anderson KB, Coons JC, Smith RB, Meyer SM, Parker LS, Empey PE. Advancing Pharmacogenomics Education in the Core PharmD Curriculum through Student Personal Genomic Testing. Am J Pharm Educ. 2016 Feb 25;80(1):3. doi: 10.5688/ajpe8013. PMID: 26941429.
Romagnoli KM, Boyce RD, Empey PE, Adams S, Hochheiser H. Bringing clinical pharmacogenomics information to pharmacists: A qualitative study of information needs and resource requirements. Int J Med Inform. 2016 Feb;86:54-61. PMID: 26725696.
Willyerd FA, Empey PE, Philbrick A, Ikonomovic MD, Puccio AM, Kochanek PM, Okonkwo DO, Clark RS. Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans. J Neurotrauma. 2016 Jan 15;33(2):226-31. doi: 10.1089/neu.2015.3879. PMID: 25891836.
Margulies S, Anderson G, Atif F, Badaut J, Clark R, Empey P, Guseva M, Hoane M, Huh J, Pauly J, Raghupathi R, Scheff S, Stein D, Tang H, Hicks M. J Neurotrauma. 2016 Jan 1;33(1):101-12. Combination Therapies for Traumatic Brain Injury: Retrospective Considerations. PMID: 25970337.
Kochanek PM, Jackson TC, Ferguson NM, Carlson SW, Simon DW, Brockman EC, Ji J, Bayır H, Poloyac SM, Wagner AK, Kline AE, Empey PE, Clark RS, Jackson EK, Dixon CE. Emerging therapies in traumatic brain injury. Semin Neurol. 2015 Feb;35(1):83-100. PMID: 25714870.
Callaway CW, Elmer J, Guyette FX, Molyneaux BJ, Anderson KB, Empey PE, Gerstel SJ, Holquist K, Repine MJ, Rittenberger JC. Dexmedetomidine Reduces Shivering during Mild Hypothermia in Waking Subjects. PLoS One. 2015 Aug 3;10(8):e0129709. PMID: 26237219.
Zhang W, Parniak MA, Sarafianos SG, Empey PE, Rohan LC. In vitro transport characteristics of EFdA, a novel nucleoside reverse transcriptase inhibitor using Caco-2 and MDCKII cell monolayers. Eur J Pharmacol. 2014 Mar 29;732C:86-95. PMID: 24690257.
Smithburger PL, Smith RB, Kane-Gill SL, Empey PE. Patient predictors of dexmedetomidine effectiveness for sedation in intensive care units. Am J Crit Care. 2014 Mar;23(2):160-5. PMID: 24585165
Holliday SF, Kane-Gill SL, Empey PE, Buckley MS, Smithburger PL. Interpatient variability in dexmedetomidine response: a survey of the literature. ScientificWorldJournal. 2014 Jan 16;2014:805013. PMID: 24558330.
Empey PE, de Mendizabal NV, Bell MJ, Bies RR, Anderson KB, Kochanek PM, Adelson PD, Poloyac SM; Pediatric TBI Consortium: Hypothermia Investigators. Crit Care Med. 2013 Oct;41(10):2379-87. PMID: 23896831.
Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury. Cousar JL, Conley YP, Willyerd FA, Sarnaik AA, Puccio AM, Empey PE, Kochanek PM, Bell MJ, Okonkwo DO, Clark RS. Neurocrit Care. 2013 Oct;19(2):192-8. doi: 10.1007/s12028-013-9881-7. PMID: 23896815.
Boyce RD, Freimuth RR, Romagnoli KM, Pummer T, Hochheiser H, Empey PE. Toward semantic modeling of pharmacogenomic knowledge for clinical and translational decision support. AMIA Summits Transl Sci Proc. 2013 Mar 18;2013:28-32. PMID: 24303292.
Poloyac SM, Empey PE. Drug dosing during hypothermia: to adjust, or not to adjust, that is the question. Pediatr Crit Care Med. 2013 Feb;14(2):228-9. PMID: 23388572.
Empey PE, Miller TM, Philbrick AH, Melick JA, Kochanek PM, Poloyac SM. Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest. Crit Care Med. 2012 Apr;40(4):1221-8.
Zhou J, Empey PE, Bies RR, Kochanek PM, Poloyac SM. Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism. Drug Metab Dispos. 2011 Dec;39(12):2209-18.
Poloyac SM, Empey KM, Rohan LC, Skledar SJ, Empey PE, Nolin TD, Bies RR, Gibbs RB, Folan M, Kroboth PD. Core Competencies for Research Training in the Clinical Pharmaceutical Sciences at the University of Pittsburgh School of Pharmacy. Am J Pharm Educ. 2011 Mar 10;75(2):27. PMID:21519417. PMCID: PMC3073101
Salonia S, Empey PE, Poloyac SM, Wisniewski SR, Klamerus M, Ozawa H, Wagner AK, Ruppel R, Bell MJ, Feldman K, Adelson D Clark RS, Kochanek PM. Endothelin-1 is increased in cerebrospinal fluid and associated with unfavorable outcomes in children after severe traumatic brain injury. J Neurotrauma. 2010 Oct;27(10):1819-25. PMID: 20684675.
Empey PE. Genetic predisposition to adverse drug reactions in the intensive care unit. Crit Care Med. 2010 Jun;38(6 Suppl):S106-16. PMID: 20502164.
Hostler D, Zhou JQ, Tortorici MA, Bies RR, Rittenberger JC, Empey PE, Kochanek PM, Callaway CW and Poloyac SM. Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers. Drug Metab Dispos. 2010 May;38(5):781-8. PMID: 20164112.
Hicks SD, Salcido DD, Logue ES, Suffoletto BP, Empey PE, Poloyac SM, Miller D, Callaway CW, Menegazzi JJ. Lipid emulsion combined with epinephrine and vasopressin does not improve survival in a swine model of bupivacaine-induced cardiac arrest. Anesthesiology. 2009 111: 138-46. PMID: 19512878.
Wang L, Leggas M, Goswami M, Empey PE, McNamara PJ. GF120918 as a chemical Abcg2 knockout model to study nitrofurantoin transfer into milk. Drug Metab Dispos. 2008 Dec;36(12):2591-6. PMID: 18799806
Hatton J, Rosbolt MB, Empey PE, Kryscio R, Young B. Dosing and safety of cyclosporine in patients with severe brain injury. J Neurosurg. 2008 Oct;109(4):699-707. PMID: 18826358
Smith KM, Trapskin PJ, Empey PE, Hecht KA, Armitstead JA. Internally-Developed Online Adverse Drug Reaction and Medication Error Reporting Systems. Hospital Pharmacy. 2006 May; 41(5): 428-436.
Empey PE, McNamara PJ, Young B, Rosbolt MB, Hatton J. Cyclosporin A Disposition following Acute Traumatic Brain Injury. J Neurotrauma. 2006 Jan; 23(1): 109-16. PMID: 16430377
Empey PE, Jennings HR, Thornton AC, Rapp RP, Evans ME. Levofloxacin failure in a patient with pneumococcal pneumonia. Ann Pharmacother. 2001 Jun;35:687-90. PMID: 11408985
Young Investigator Award, Society of Critical Care Medicine, January 2013.
“Creating data-driven systems to personalize care through pharmacogenomics”. Fondazione Ri.MED Personalized Medicine in Rome, Italy. October 2015.
“PGx Test2LearnTM: Advancing pharmacogenomics education in the core PharmD curriculum through student personal genomic testing.” American Association of Colleges of Pharmacy in National Harbor, MD. July 2015.
“Graduate Education SIG: A Cross-Institutional Approach to Multi-Disciplinary Graduate Education and Personal Strengths Development for Team Science and Business Meeting.” American Association of Colleges of Pharmacy in National Harbor, MD. July 2015.
"Pharmacogenomics: Pitt’s Prescription for Personalized Medicine” University of Pittsburgh Winter Academy in West Palm Beach, FL and Naples, FL. March 2015.
"Testing Considerations for the Application of Pharmacogenomics”. American Society of Health-system Pharmacists, Anaheim CA. December, 2014
“Pharmacogenomics in critical care." SCCM Critical Care Congress in San Francisco, CA. . January 2014.
” Personalizing drug therapy through pharmacogenomics”. University of Pittsburgh Science 2013: Convergence conference in Pittsburgh, PA. October 2013.
“Lost in translation: The importance of understanding clinical pharmacology in neurotrauma research.” National Neurotrauma Symposium, Nashville, TN. August, 2013.
“Development of a graduate level cross-institutional course to foster an understanding of translational sciences.” American Association of Colleges of Pharmacy in Chicago, IL. July 2013
“Phenytoin levels are elevated in children receiving therapeutic hypothermia following traumatic brain injury.” ACRT/SCTS Joint Annual Meeting. Washington, DC April, 2013.
“Ethnic variation in drug response: Is it all pharmacogenetics?”. SCCM Critical Care Congress in San Juan, Puerto Rico. January 2013.
“Phenytoin concentrations are elevated in children receiving therapeutic hypothermia following traumatic brain injury”. SCCM Critical Care Congress in San Juan, Puerto Rico. January 2013.
“Implementing Pharmacogenomics to Achieve Personalized Medicine”. Department of Biomedical Informatics Colloquium. December 2012.
“Advancing Pharmaceutical Care Through Pharmacogenomics”. University of Pittsburgh Medical Center Department of Pharmacy Grand Rounds. November 2012.
“Pharmacogenomics in Cardiology: A Future for Personalized Medicine?”. University of Pittsburgh School of Pharmacy Fall Continuing Education Program in Pittsburgh, PA. October 2012.
“Probenecid increases n-acetylcysteine brain penetration following experimental pediatric traumatic brain injury.” 30th Annual National Neurotrauma Symposium, Phoenix, AZ. July, 2012.
"Effect of mild therapeutic hypothermia on fentanyl and midazolam clearance in a rat model of cardiac arrest." ACRT/SCTS Joint Annual Meeting. Washington, DC. April, 2011.
"Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury in humans." SCCM Critical Care Congress in San Diego, CA. January 2011.
“Effect of moderate induced hypothermia on fentanyl and midazolam clearance in a rat model of hypoxic cardiac arrest”. SCCM Critical Care Congress in Miami, FL. January 2010.
“The history of the Pharmacokinetics/Pharmacodynamics PRN. ACCP Annual Meeting, Anaheim, CA October, 2009.
"Microarray expression profiling of xenobiotic transporters in the human lactating mammary epithelial cells." AAPS Workshop on Drug Transporters in ADME: From the Bench to the Bedside, March 2009.
“A UPLC-MS/MS method for determination of CSF fentanyl concentrations in pediatric TBI patients receiving therapeutic hypothermia.” Society of Critical Care Medicine 38th Critical Care Congress, Nashville, TN. January 2009.
“Breast cancer resistance protein (Bcrp1/Abcg2) transports of nitrofurantoin, cimetidine, and PhIP in the CIT3 cell culture model of lactation.” The 14th North American Meeting of the International Society for the Study of Xenobiotics, Rio Grande, Puerto Rico. October 2006.
“PhIP transport in ABCG2 stably transfected MDCKII cells.” AAPS Meeting, San Antonio, TX. November 2006.
“Xenobiotic transporter gene expression in lactating mammary epithelium.” AAPS Annual Meeting in Baltimore, MD. November 2004.