I received an M.A. degree in mathematical statistics (1985) and M.S. and Ph.D. degrees (1982 and 1990) in applied statistics. Following a staff position at the University of Pittsburgh Medical School, I was appointed to the faculty in 1995 as Assistant Professor. I was promoted to Associate Professor of Pharmaceutical Sciences and Psychiatry in 2003 and Professor in 2010, and tenured in 2013. I have been Co-Principal Investigator and Director of the Methodology and Statistics Core of the NIDA-funded Center for Education and Drug Abuse Research since 1995. I am the recipient of Independence Scientist Award since 2005.

My primary expertise and research focus are devising and evaluating psychometric tools. With support from Independent Scientist Award since 2005,he has spearheaded development of an interval scale to measure the psychological components of SUD liability common across the DSM-IV categories. Employing item response theory, in conjunction with longitudinal multivariate modeling, a scale termed the liability index has been provisionally validated to quantify SUD risk at ages 10-12, 12-14, 16 and 19 in boys and age 10-12 in girls. This research will be extended in the forthcoming period of the K02 to encompass the period of risk up to age 30 in males and age 28 in females.

Notably, my work in instrument development has been integrated into investigations of SUD etiology, including measurement of social cognition, decision making and biological mechanisms. In this facet of my research, I have focused on a cardinal component of the SUD liability phenotype, termed neurobehavior disinhibition. This research has been informative for elucidating the neurological, endocrinoIogical, and social contextual aspects of SUD etiology as well as longitudinally distinct trajectories to SUD. I have also conceptualized and empirically validated a novel framework for measuring substance use topology during adolescence and proposed a model of symptom definitions for adolescent SUD.

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