Yong Tae Kwon, associate professor of pharmaceutical sciences, received a four-year, $1,488,137 grant from the National Institutes of Health for "Role of Ubiquitin in Cardiovascular System."
The N-end rule proteolytic system recognizes specific N-terminal amino acids of short-lived proteins, such as arginine, which is generated by an enzyme called ATE1 R-transferase. The goal of this study is to investigate how arginylation of specific proteins controls signaling pathways in the heart and blood vessels through hypoxia-sensitive degradation of their regulators.
