I am a pharmacy graduate with a Bachelor's degree in Pharmaceutical Sciences from SRM University, India; and a Master's degree in Pharmaceutical Chemistry from Acharya Nagarjuna University, India. After 2 years of teaching experience, I joined as a research scholar under Dr. Sandip B. Bharate in the Natural Products & Medicinal Chemistry division of CSIR-IIIM, Jammu and worked extensively on natural product driven drug discovery for Alzheimer's disease and cancer. Further, I have completed my PhD in the faculty of Chemical Sciences by working on the discovery of natural product based multitargeted anti-Alzheimer's agents under the supervision of Dr. Sandip B. Bharate. As a postdoctoral associate in Dr. Journigan's lab I will be working on the design and synthesis of TRPM8 antagonists.
1. V. K. Nuthakki, S. Choudhary, C. N. Reddy, S. Bhatt, A. Jamwal, A. Jotshi, R. Raghuvanshi, A. Sharma, S. Thakur, H. R. Jadhav, S. S. Bharate, U. Nandi, A. Kumar, and S. B. Bharate, Design, Synthesis, and Pharmacological Evaluation of Embelin−Aryl/alkyl Amine Hybrids as Orally Bioavailable Blood−Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer’s Disease: Discovery of SB-1448. ACS Chem. Neurosci., DOI: 10.1021/acschemneuro.3c00030. (IF: 5.78)
2. V. K. Nuthakki, R. Mudududdla, S. B. Bharate, Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids. Eur. J. Med. Chem., 2022, 227, 113938. (IF: 7.088)
3. V. K. Nuthakki, R. R. Y. Bheemanaboina, S. B. Bharate, Identification of aplysinopsin as a blood-brain barrier permeable scaffold for anti-cholinesterase and anti-BACE-1 activity. Bioorg. Chem., 2021, 107 104568. (IF: 5.307)
4. V. K. Nuthakki, R. Mudududdla, A. Sharma, A. Kumar, S.B. Bharate, Synthesis and biological evaluation of indoloquinoline alkaloid cryptolepine and its bromo-derivative as dual cholinesterase inhibitors. Bioorg. Chem., 2020, 90,103062. (IF: 5.307)
5. V. K. Nuthakki, A. Sharma, A. Kumar, S.B. Bharate, Identification of embelin, a 3-undecyl-1,4-benzoquinone from Embelia ribes as a multitargeted anti-Alzheimer agent. Drug Dev. Res., 2019, 80(5), 655-665. (IF: 5.004)
6. N. Augustin,# V. K. Nuthakki,# M. Abdullaha, Q. P. Hassan, S. G. Gandhi, and S. B. Bharate, Discovery of Helminthosporin, an Anthraquinone Isolated from Rumex abyssinicus Jacq as a Dual Cholinesterase Inhibitor. ACS Omega, 2020, 5, 3, 1616–1624. #equally contributed as first author. (IF: 4.132)
7. I. S. Williams,# S. Chib,# V. K. Nuthakki,# L. Gatchie, P. Joshi, N. A. Narkhede, R. A. Vishwakarma, S. B. Bharate, S. Saran and B. Chaudhuri, Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme. J. Agric. Food Chem., 2017, 65, 7440-7446. # equally contributed as first author. (IF: 5.279)
8. M. Sharma, Design, A. Sharma, V. K. Nuthakki, and S. B. Bharate, Synthesis, and Structureâ€activity Relationship of Caffeineâ€based Triazoles as Dual AChE and BACEâ€1 inhibitors. Drug Dev. Res., 2022, 10.1002/ddr.21998. (IF: 5.004)
9. R. Banoo, V. K. Nuthakki, M. Abdullaha, M. Sharma, and S. B. Bharate, Blood–brain barrier permeable benzylpiperidinâ€4â€ylâ€linked benzylamino benzamides as dual cholinesterase inhibitors. Drug Dev. Res., 2022, 10.1002/ddr.21997. (IF: 5.004)
10. A. Sharma, V. K. Nuthakki, S. Gairola, B. Singh, and S. B. Bharate, A Coumarin-Donepezil Hybrid as a Blood-Brain Barrier Permeable Dual Cholinesterase Inhibitor: Isolation, Synthetic Modifications, and Biological Evaluation of Natural Coumarins. ChemMedChem., 2022, e202200300. (IF: 3.54)
11. R. Raghuvanshi, V. K. Nuthakki, L. Singh, B. Singh, S.S. Bharate, R. Bhatti, S.B. Bharate, Identification of plant-based multitargeted leads for Alzheimer's disease: In-vitro and in-vivo validation of Woodfordia fruticosa (L.) Kurz, Phytomedicine, 2021, 91,153659. (IF: 6.656)
12. C. Prabhakara, R. Godbole, P. Sil, S. Jahnavi, S.E. Gulzar, T.S. van Zanten, D. Sheth, N. Subhash, A. Chandra, A. Shivaraj, P. Panikulam, I. U, V. K. Nuthakki, T.P. Puthiyapurayil, R. Ahmed, A.H. Najar, S.M. Lingamallu, S. Das, B. Mahajan, P. Vemula, S.B. Bharate, P.P. Singh, R. Vishwakarma, A. Guha, V. Sundaramurthy, S. Mayor, Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors, PLoS pathog., 2021, 17(7), e1009706. (IF: 7.464)
13. M. Abdullaha, V. K. Nuthakki, S. B. Bharate, Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. Eur. J. Med. Chem., 2020, 207, 112761. (IF: 7.088)
14. S. Mahajan, N. Slathia, V. K. Nuthakki, S. B. Bharate and K. K. Kapoor, Malononitrile-activated synthesis and anticholinesterase activity of styrylquinoxalin-2(1H)-ones. RSC Adv., 2020, 10, 15966. (IF: 4.036)
15. S. B. Bharate, V. Kumar, S. K. Jain, M. J. Mintoo, S. K. Guru, V. K. Nuthakki, M. Sharma, S. S. Bharate, S. G. Gandhi, D. M. Mondhe, S. Bhushan and R. A. Vishwakarma, Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor. J. Med. Chem., 2018, 61, 1664-1687. (IF: 8.039)
